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RhinoBalls 08-01-2012 07:15 AM

Huperzine A
Supplementing with this memory drug for rapid strength/endurance gains? plausible

"There is a class of compounds called Acetylcholineesterase inhibitors, that inihibit acetylcholineesterase, which is responsible for deactivating acetylcholine in the brain. Guess what? Acetylcholine is a very effective inhibitor of Somatostatin. Therefore Acetylcholineesterase inhibitors are indirect somatostatin inihibitors, working by increasing acetylcholine levels which then inhibit somatostatin levels.

Does this really work? YES, its been clinically proven in numerous studies with stunning results. In the studies they used GHRH + Acetylcholineesterase inhibitor Pyrostigmine at a dosage of 120mg. What the study found is that orally administering Pyrostigmine, an acetylcholineesterase inhibitor, and then injecting GHRH vs. the placebo/control group resulted in a dramatically larger amount of GH released in response to the same dosage of GHRH. This is because somatostatin levels were dramatically lowered, and allowed an even larger amount of GH to be released in response to GHRH.

Had the study used CJC-1295 they wouldve had a far greater result. Not only would more GH be released per surge, but they wouldve had an endless or damn near endless surge of GH release, rather than the normal "Pulsatile" release system which is controlled by:

A) The short duration of GHRH and other endogenous secretagogues (overcome with CJC-1295)

B) The GH-inhibitory action of Somatostatin (overcome with acetylcholineesterase inhibitors)

Acetylcholineesterase inhibitors are taken orally, they are legal and readily available for purchase as they are extracted from natural plant sources. They are CHEAP, costing just a dollar or less per day to use in conjunction with CJC-1295. By taking them you can use a lower CJC-1295 dosage and still get much greater results.

Normally the pituitary functions like this;
1) Endogenous GH secretagogue such as GHRH or Ghrelin, signals pituitary to release HGH, the amount of GH released is controlled by somatostatin and GHRH quantity.
2) Pituitary releases HGH creating a 'surge', immediately after, somatostatin levels rise thus making the pituitary unresponsive to GHRH or other secretagogues, GHRH remaining becomes deactivated due to proteocyltic cleavage.
3) After the HGH released has become deacticated by the body, Somatostatin levels begin to decrease again, and once more endogenous secretagogues arrive, another surge will occur and repeat process.

The pituitary function using CJC-1295 + a somatostatin inhibitor (in this case acetylcholineesterase inhibitors), functions like this:
1) Exogenously supplied GH secretagogue CJC-1295 signals pituitary to release HGH, the amount of GH released is GREATER than without acetylcholineesterase inhibitor due to suppression of somatostatin.
2) Pituitary releases HGH creating a surge, however, somatostatin levels fail to rise after the release, therefore the pituitary remains responsive to secretagogues to signal more release of HGH, and the CJC-1295 fails to degrade due to its design thus lasting 24 hours a day for 8-10 days from an injection.
3) After the HGH is released, ANOTHER surge is immediatley signalled by the still active CJC-1295, and then another surge, and another, and another, and another, and another, and in the time span that 1 natural surge wouldve happened and another would be ready to go, probably 20x as many surges have already occured.

So for just 50 extra cents a day and the consumption of an oral pill of a legal, readily available compound, you can ABSURDLY modify the pituitary response to CJC-1295 by suppressing Somatostatin.

Theres 3 common acetylcholineesterase inhibitors, they are;

Pyrostigmine (120mg/ed)
Galantamine (8-16mg/ed)
Huperzine A (50-150mcg/ed)"

It seems that an effective way to increase strength without adding much (if any) mass would be to enhance the strength of our neurological muscular contractions. Since huperzine A allows for greater production of acetylcholine, one can assume it's possible to amplify the electrical impulses, increase motor units and therefor increase strength.

I'm going to be testing it out.

Narkissos 08-02-2012 12:48 PM


BTS 01-12-2013 04:38 PM

bump for results/outcome

Narkissos 01-18-2013 09:19 PM

I'm curious as well... as I would like to give it a try.


RhinoBalls 01-19-2013 02:26 PM

I can quite happily state this works. not necessarily drastic leaps and feats of extreme physical strength but if you've had a long day or are planning a particularly heavy workout. this is what you want.

There are too many variables to say that all of my good workouts are because of this. but there is a definite correlation.

my squat was stuck for the longest time. But i've noticed after i've taken some huperzine A the weight doesn't feel as heavy. I've managed to hit my 1rm -5kg for 6 reps, then gone in a few days later without taking huperzine A and failed at 90% of my 1rm (bearing in mind i was maxing out at squats damn near everyday so exhaustion or under recovery doesn't play a factor here)

Only problem is a friend of mine (who is a powerlifter and a GP) told me that long term use of huperzine A can lead to decreased levels of acetylcholine in the long run. and offered to show me some studies. I'm sure if you're interested you could dig something up on google.

So is it effective? fuck yeah. would i recommend it? fuck yeah. Is it something that you should dose regularly? probably, no.

BTS 01-19-2013 03:29 PM

supplementing w/ choline can aide in the maintenance of acetylcholine (ACh) levels. Which is a common protocol for those who take piracetam. (other Noo's as well, but that's a common combo)

Personally I stopped supplementing w choline (i forget why exactly) and still take piracetam daily. Not sure if my ACh level has been affected by doing so.

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